Evaluation of handwriting kinematics and pressure for differential diagnosis of Parkinson's disease

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Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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DROTÁR Peter MEKYSKA Jiří REKTOROVÁ Irena MASÁROVÁ Lucia SMÉKAL Zdeněk FAUNDEZ-ZANUY Marcos

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Artificial Intelligence in Medicine
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.artmed.2016.01.004
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova Decision support system; Support vector machine classifier; Handwriting database; Handwriting pressure; Parkinson's disease; PD dysgraphia
Popis Objective: We present the PaHaW Parkinson's disease handwriting database, consisting of handwriting samples from Parkinson's disease (PD) patients and healthy controls. Our goal is to show that kinematic features and pressure features in handwriting can be used for the differential diagnosis of PD. Methods and material: The database contains records from 37 PD patients and 38 healthy controls performing eight different handwriting tasks. The tasks include drawing an Archimedean spiral, repetitively writing orthographically simple syllables and words, and writing of a sentence. In addition to the conventional kinematic features related to the dynamics of handwriting, we investigated new pressure features based on the pressure exerted on the writing surface. To discriminate between PD patients and healthy subjects, three different classifiers were compared: K-nearest neighbors (K-NN), ensemble AdaBoost classifier, and support vector machines (SVM). Results: For predicting PD based on kinematic and pressure features of handwriting, the best performing model was SVM with classification accuracy of P-acc = 81.3% (sensitivity P-sen = 87.4% and specificity of P-spe = 80.9%). When evaluated separately, pressure features proved to be relevant for PD diagnosis, yielding P-acc = 82.5% compared to P-acc = 75.4% using kinematic features. Conclusion: Experimental results showed that an analysis of kinematic and pressure features during handwriting can help assess subtle characteristics of handwriting and discriminate between PD patients and healthy controls.
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