Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

• Autoři: POLANSKÁ Hana; HEGER Zbynek; GUMULEC Jaromír; RAUDENSKÁ Martina; SVOBODOVÁ Markéta; BALVAN Jan; FOJTŮ Michaela; BINKOVÁ Hana; HORÁKOVÁ Zuzana; KOSTŘICA Rom; ADAM Vojtech; KIZEK Rene; MASAŘÍK Michal
• Rok publikování: 2016
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Tumor Biology
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: http://dx.doi.org/10.1007/s13277-015-4569-6
• Obor: Onkologie a hematologie
• Klíčová slova: Head and neck cancer; Human papillomavirus; Tumor markers; Kaplan-Meier analysis
• Popis: Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.

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• Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.
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