Flow cytometry in immunoglobulin light chain amyloidosis: Short review

• Autoři: FILIPOVA Jana; ŘÍHOVÁ Lucie; VŠIANSKÁ Pavla; KUFOVA Zuzana; KRYUKOVA Elena; KRYUKOV Fedor; HAJEK Roman
• Rok publikování: 2015
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Leukemia Research
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: http://dx.doi.org/10.1016/j.leukres.2015.07.002
• Obor: Onkologie a hematologie
• Klíčová slova: Flow cytometry; AL amyloidosis; Monoclonal gammopathy; Plasma cell
• Popis: Flow cytometry (FCM) has found its application in clinical diagnosis and evaluation of monoclonal gammopathies (MG). Although, research has been mainly focused on multiple myeloma (MM), nowadays FCM becomes to be potential tool in the field of AL amyloidosis. Clonal plasma cells identification and specific phenotype profile detection is important for diagnosis, monitoring and prognosis of AL amyloidosis. Therefore, FCM could be a perspective method for study not only MM but also AL amyloidosis. This review provides an overview and possibilities of FCM application in AL amyloidosis. (C) 2015 Elsevier Ltd. All rights reserved.

Související projekty

• Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií