Resting heart rate does not predict cardiovascular and renal outcomes in type 2 diabetic patients
| Autoři | |
|---|---|
| Rok publikování | 2016 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Diabetes Research |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.hindawi.com/journals/jdr/2016/6726492/ |
| Doi | http://dx.doi.org/10.1155/2016/6726492 |
| Obor | Endokrinologie, diabetologie, metabolismus, výživa |
| Klíčová slova | Diabetic kidney disease |
| Popis | Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 patients at baseline, DKD (glomerular filtration rate 60ml/min or proteinuria) was present in 328 at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss more than3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses significant differences in the cumulative incidence of the studied outcomes, i.e. progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event and all-cause mortality, between RHR 65 (arbitrary cut-off) or 75 (median) bpm were not found. We did not ascertained predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in the Czech Republic. |
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