MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma.

Logo poskytovatele

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
Autoři

VYCHYTILOVÁ Petra KISS Igor KLUSOVÁ Soňa HLAVSA Jan PROCHÁZKA Vladimír KALA Zdeněk MAZANEC Jan HAUSNEROVÁ Jitka KŘEN Leoš HERMANOVÁ Markéta LENZ Jiří KARÁSEK Petr VYZULA Rostislav SLABÝ Ondřej

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Diagnostic Pathology
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.diagnosticpathology.org/content/pdf/s13000-015-0272-6.pdf
Doi http://dx.doi.org/10.1186/s13000-015-0272-6
Obor Onkologie a hematologie
Klíčová slova microRNA; pancreatic ductal adenocarcinoma; diagnostic biomarkers; prognostic biomarkers; chronic pancreatitis
Přiložené soubory
Popis Background: Pancreatic ductal adenocarcinoma is an aggressive malignancy with late presentation, metastatic potential and very poor prognosis. Therefore, there is an urgent need for novel diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Altered expression of microRNAs has been reported in wide range of malignancies, including pancreatic ductal adenocarcinoma. The aim of this study was to analyze the expression of selected microRNAs in normal pancreas, chronic pancreatitis and pancreatic ductal adenocarcinoma tissues and evaluate their diagnostic and prognostic potential. Findings: Using quantitative real-time PCR, expression levels of 4 microRNAs were examined in 74 tumor tissues, 18 tissues of chronic pancreatitis and 9 adjacent normal tissues and correlated with clinicopathological features of patients. Expression levels of miR-21, miR-34a and miR-198 were significantly higher, whereas levels of miR-217 were significantly lower in pancreatic ductal adenocarcinomas compared to healthy tissues and tissues of chronic pancreatitis. Moreover, increased expression of miR-21 and miR-198 was significantly associated with shorter disease free survival and overall survival. Conclusions: Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info