Coincidence of ANKRD1, TMEM43and PKP2 mutations in patient with ARVD

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Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SKUTKOVÁ Linda GROCHOVÁ Diana GROCHOVÁ Ilga HRSTKOVÁ Hana

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Experimental and Clinical Cardiology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova ANKRD1; Arrhythmogenic right ventricular dysplasia; Cardiomyopathy; Next generation sequencing; PKP2; TMEM43
Popis Arrhythmogenic right ventricular dysplasia (ARVD) is a serious genetic disorder, usually with autosomal dominant inheritance, which can lead to sudden cardiac death in young individuals and athletes. The genes known to be associated with ARVD are five genes for desmosome proteins plus another three for non-desmosomal proteins. Here we present a patient with serious symptoms of ARVD (including ventricular tachycardia and sudden cardiac arrest), who carries three potentially pathological mutations in three diffe rent genes. Two missense mutations in ANKRD1 and TMEM43 gene respectively and one mutation, in PKP2, which causes aberrant splicing were detected. We hypothesized that the combination of these three pathological mutations could be the reason for the lethal course of the disease. Moreover, we assume that mutations in ANKRD1 gene, which were previously shown to be responsible for dilated cardiomyopathy and hypertrophic cardiomyopathy, could be associated also with ARVD.

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