Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies

Varování

Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	BIENERTOVÁ VAŠKŮ Julie BIENERT Petr ZLÁMAL Filip ŠPLÍCHAL Zbyněk TOMANDL Josef TOMANDLOVÁ Marie HODICKÁ Zuzana VENTRUBA Pavel VAŠKŮ Anna
Rok publikování	2013
Druh	Článek v odborném periodiku
Časopis / Zdroj	JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.3109/01443615.2013.776026
Obor	Gynekologie a porodnictví
Klíčová slova	Brain-derived neurotrophic factor; ciliary neurotrophic factor; pre-eclampsia
Přiložené soubory	brain_derived.pdf
Popis	The aim of the study was to investigate the circulating levels of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in maternal serum and umbilical cord blood from respective pregnancies in pre-eclampsia (PE) cases and a control cohort. A total of 12 pre-eclampsia cases and 34 healthy controls were enrolled and the maternal peripheral blood - umbilical cord blood duos, were examined for BDNF and CNTF levels. BNDF levels were significantly higher in umbilical cord blood from pre-eclamptic pregnancies; there was also significant difference between maternal plasma and umbilical cord blood levels of BDNF (p < 0.001) in the controls. The CNTF levels in umbilical cord blood (CNTF-UCB) were significantly higher in PE cases than in the controls (p = 0.03). Significant differences were observed in expression of BDNF and CNTF proteins in maternal peripheral blood and umbilical cord blood between pre-eclampsia cases and healthy controls.