The impact of body mass index on the development of systemic inflammatory response syndrome and sepsis in patients with polytrauma

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Publikace nespadá pod Fakultu sportovních studií, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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VOMELA Jindřich MICA Ladislav KEEL Marius TRENTZ Otmar

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Injury
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.injury.2012.11.015
Obor Traumatologie a ortopedie
Klíčová slova Body mass index; Polytrauma; SIRS; Sepsis; C-reactive protein; Interleukin-6; Procalcitonin
Přiložené soubory
Popis Obesity is a growing problem in industrial nations. Our aim was to examine how overweight patients coped with systemic inflammatory response syndrome (SIRS) after polytrauma. A total of 651 patients were included in this retrospective study, with an ISS 16 and age 16 years. The sample was subdivided into three groups: body mass index (BMI; all in kg/m2)<25, BMI 25–30 and BMI>30, or low, intermediate and high BMI. The SIRS score was measured over 31 days after admission together with measurements of C-reactive protein (CRP), interleukin-6 (IL-6) and procalcitonin (PCT). Data are given as the mean +/- SEM if not otherwise indicated. Kruskal–Wallis and x2 tests were used for statistical analysis and the significance level was set at <.05. The maximum SIRS score was reached in the low BMI-group at 3.4 +/- 0.4, vs. 2.3 +/- 0.1 and 2.5 +/- 0.2 in the intermediate BMI-group and high BMI-group, respectively (p<.0001). However, the maximum SIRS score was reached earlier in the BMI 25–30 group at 1.8 +/- 0.2 days, vs. 3.4 +/- 0.4 and 2.5 +/- 0.2 days in the BMI <25 and BMI >30 groups, respectively (<.0001). The incidence of sepsis was significantly higher in the low BMI group at 46.1%, vs. 0.2% and 0% in the BMI 25–30 and BMI >30 groups, respectively (<.0001). No significant differences in the CRP, IL-6 or PCT levels were found between groups. A higher BMI seemed to be protective for these patients with polytrauma-associated inflammatory problems.

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