Pluripotent stem cells and gene therapy

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ŠIMARA Pavel MOTL Jason KAUFMAN Dan

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Translational Research
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
www PubMed
Doi http://dx.doi.org/10.1016/j.trsl.2013.01.001
Obor Genetika a molekulární biologie
Klíčová slova pluripotent stem cells; gene therapy
Popis Human pluripotent stem cells represent an accessible cell source for novel cell-based clinical research and therapies. With the realization of induced pluripotent stem cells (iPSCs), it is possible to produce almost any desired cell type from any patient's cells. Current developments in gene modification methods have opened the possibility for creating genetically corrected human iPSCs for certain genetic diseases that could be used later in autologous transplantation. Promising preclinical studies have demonstrated correction of disease-causing mutations in a number of hematological, neuronal, and muscular disorders. This review aims to summarize these recent advances with a focus on iPSC generation techniques, as well as gene modification methods. We will then further discuss some of the main obstacles remaining to be overcome before successful application of human pluripotent stem cell-based therapy arrives in the clinic and what the future of stem cell research may look like.
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