Project information
Development of a microfluidic system for the In vitro generation of retinal organoids.
- Project Identification
- MUNI/IGA/1297/2021
- Project Period
- 1/2022 - 12/2022
- Investor / Pogramme / Project type
-
Masaryk University
- Internal grant agency MU
- MU Faculty or unit
- Faculty of Medicine
Stem cell derived retinal organoids can serve as excellent models to study eye development and diseases. However, laborious formation of the organoids and missing control of cellular microenvironment leads to high heterogeneity of produced organoids. Here we propose to overcome these issues by combination of human pluripotent stem cells with microfluidic system to optimize conditions and factors that drive morphogenesis of retinal tissue in niche controlled over time and space.
Publications
Total number of publications: 1
2024
-
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single-cell suspension
Biotechnology Journal, year: 2024, volume: 19, edition: 8, DOI