Project information
Molecular organization of the zygotic spindle apparatus in non-rodent embryos
- Project Identification
- MUNI/IGA/1127/2021
- Project Period
- 1/2022 - 12/2022
- Investor / Pogramme / Project type
-
Masaryk University
- Internal grant agency MU
- MU Faculty or unit
- Faculty of Medicine
Despite scientific advances in reproductive medicine, embryo development still holds a myriad of secrets. The reset of the cell cycle machinery driving the unification and segregation of two parental genomes in the fertilized egg is fundamental to all mammals. The proposed work will shed new light on basic cell cycle mechanisms underlying the transition from acentrosomal female meiosis to the first mitotic division in which sperm centrioles assume control of microtubule organization.
Publications
Total number of publications: 3
2024
-
Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos
Nature Communications, year: 2024, volume: 15, edition: 1, DOI
2022
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ONE STEP CHEMICAL DERIVATIZATION OF SECRETED CELL METABOLITES FOR SENSITIVE MASS SPECTROMETRY DETECTION
Year: 2022, type: Conference abstract
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The first cleavage plane in human embryos is dictated by the topology of pronuclei, not by the polar body position
Year: 2022, type: Conference abstract