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Project information
Delta podjednotka RNA polymerázy z Gram pozitivních bakterií (DELTA)

Information

This project doesn't include Faculty of Sports Studies. It includes Central European Institute of Technology. Official project website can be found on muni.cz.
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Project Identification
GA204/09/0583
Project Period
1/2009 - 12/2012
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Central European Institute of Technology
Keywords
RNA polymerase
Cooperating Organization
Institute of Microbiology of the ASCR, v. v. i.
  • Responsible person Mgr. Libor Krásný, Ph.D.

To efficiently fight bacterial diseases and infections, knowledge of the molecular mechanisms used by these organisms is required. Bacterial RNA polymerase (RNAP) is an essential multisubunit enzyme. Contrary to the well studied RNAPs from gram negative bacteria, gram positive RNAPs contain the d subunit. Its role in the cell is not well understood. We propose to conduct structural, genetic, and biochemical studies to define its role in gene expression regulation. We propose to solve the 3D structure of delta, determine its position within RNAP, and use this new knowledge to define its physiological role in the cell.

Publications

Total number of publications: 19

2013

2012

2011

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