Project information
Personalized Medicine – Diagnostics and Therapy
- Project Identification
- TN01000013
- Project Period
- 1/2019 - 12/2022
- Investor / Pogramme / Project type
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Technology Agency of the Czech Republic
- National competence centers 1
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Physiology of the ASCR, v. v. i.
Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
- Responsible person Doc. Ing. Martin Fusek, CSc.
Palacký University, Olomouc
Technical University Ostrava
Prague Institute of Chemical Technology
University Hospital Olomouc
St. Anne's University Hospital Brno
University Hospital Brno-Bohunice
General Teaching Hospital Praha
IntellMed, s.r.o.
Institute of Applied Biotechnologies a.s.
APIGENEX s.r.o.
Tilia Genomic a.s.
Centrum PerMed je zaměřeno na aplikovaný výzkum v oblasti diagnostiky a terapie zřídkavých a geneticky podmíněných onemocnění. Cílem práce centra je vyvinout personalizované diagnostické metody a zároveň látky - kandidáty léčiv, které budou pomáhat specifickým skupinám pacientů. Přístup je založen na interdisciplinaritě kombinací chemie a biologie, genetiky a bioinformatiky. Celý výzkum je rozdělen do pracovních aktivit jako je validace vhodných molekulárních cílů, biologická chemie, preklinický vývoj, identifikace biomarkerů a DNA analýzu. Výsledky centra PerMed budou komercionalizovány jednak prodejem licencí a jednak vznikem spin-off společností.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 21
2022
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Virtual screening of potential anticancer drugs based on microbial products
Seminars in Cancer Biology, year: 2022, volume: 86, edition: November 2022, DOI
2021
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Computational design of enzymes for biotechnological applications
Biotechnology Advances, year: 2021, volume: 47, edition: March–April, DOI
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FireProt(DB): database of manually curated protein stability data
Nucleic acids research, year: 2021, volume: 49, edition: D1, DOI
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Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on BCR-ABL1-like subtype
Acta Oncologica, year: 2021, volume: 60, edition: 6, DOI
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Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro
Journal for ImmunoTherapy of Cancer, year: 2021, volume: 9, edition: 8, DOI
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Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond
International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 2, DOI
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Multi-pathogen infections and Alzheimer's disease
Microbial Cell Factories, year: 2021, volume: 20, edition: 1, DOI
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Web-based tools for computational enzyme design
Current Opinion in Structural Biology, year: 2021, volume: 69, edition: August 2021, DOI
2020
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Capture-based NGS panel for detection of immunoglobulin and T-cell receptor gene rearrangements in DNA samples from patients with acute lymphoblastic leukemia
Year: 2020, type: Conference abstract
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Machine Learning in Enzyme Engineering
ACS Catalysis, year: 2020, volume: 10, edition: 2, DOI