Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2015043
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publications
Total number of publications: 252
2019
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Selectively Oxidized Cellulose with Adjustable Molecular Weight for Controlled Release of Platinum Anticancer Drugs
Biomacromolecules, year: 2019, volume: 20, edition: 4, DOI
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Simultaneous study of mechanobiology and calcium dynamics on hESC-derived cardiomyocytes clusters
Journal of Molecular Recognition, year: 2019, volume: 32, edition: 2, DOI
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Structural basis for the multitasking nature of the potato virus Y coat protein
Science advances, year: 2019, volume: 5, edition: 7, DOI
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Structure-functional study of lectins: key players in a fight between host and pathogen
Year: 2019, type: Conference abstract
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Synthesis, structure, stability and phase diagrams of selected bimetallic silver- and nickel-based nanoparticles
CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY, year: 2019, volume: 64, edition: March, DOI
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The experimental and theoretical study of Bi-X (X = Sn, Ni) nanoalloys
Year: 2019, type: Conference abstract
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The first X-ray crystal structure of a mercury(II) complex with an SP(N)(3)-based ligand: Synthesis and crystal structure of SP(NC5H10)(3) and [Hg{SP(NC5H10)(3)}Cl-2](2)
Phosphorus, Sulfur, and Silicon and the related elements, year: 2019, volume: 194, edition: 1-2, DOI
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The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells
Journal of applied biomedicine, year: 2019, volume: 17, edition: 4, DOI
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The theoretical and experimental study of the Sb-Sn nano-alloys
CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY, year: 2019, volume: 64, edition: 1, DOI