Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 674
2008
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Erlotinib (Tarceva) in patients with advanced non-small lung cancer (NSCLC)-The single institution experience
Journal of Thoracic Oncology, year: 2008, volume: 3, edition: 4
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Hodnocení nutričního stavu a stanovení rizika povýživy u nemocných s bronchogenním karcinomem
Abstrakty, year: 2008
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Markers of proliferation activity in non-small cell lung cancer
Endoscopic Review, year: 2008, volume: 1, edition: 29
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Postavení biologické léčby nemalobuněčného bronchogenního karcinomu v České republice /přehled a vlastní výsledky/
Year: 2008, type: Appeared in Conference without Proceedings
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Sanace tepenného a žilního zásobení tumoru v oblasti kýčle a pánve těsně před rozsáhlým ortopedickým výkonem.
Sborník přednášek X. setkání českých a slovenských chirurgů na Moravě, year: 2008
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The incidence of serious venous thromboembolic events in 1157 lung cancer patients
European Respiratory Journal, year: 2008, volume: 32, edition: suppl 52
2007
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Endobronchial treatment in general anesthesia with jet ventilation is safe and useful procedure
Journal of Thoracic Oncology, year: 2007
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Evaluation of the prognostic role of a panel of biomarkers in stage IB-IIIA non-small cell lung cancer patients
Anticancer Research, year: 2007, volume: 27, edition: 6C
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Gefitinib toxicity has been significantly correlated with survival in non-small cell lung cancer patients treated in EAP program in Czech Republic
Journal of Thoracic Oncology, year: 2007
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Incidence trombembolických příhod u pacientů s karcinomem plic v letech 2004-2006
Sborník, XV. Západočeské pneumoonkologické dny Plzeň, year: 2007