Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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Health and environmental problems of using anti-armour munitions containing depleted uranium core
Chemické Listy, year: 2002, volume: 96(S), edition: 1
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Health and environmental problems of using anti-armour munitions containing depleted uranium core
EuPRA Conference: Europe as a Peaceful Power?, year: 2002
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Human health risks of cyanobacterial toxins (microcystins) in Brno reservoir
SECOTOX 2002, Trends and Advances in Environmental Chemistry and Ecotoxicology, Book of Abstracts, year: 2002
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Characterization of estrogenic activity of riverine sediments from the Czech Republic
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, year: 2002, volume: 43, edition: 2
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Chemical profile and contribution of PAHs to in vitro toxic potencies of urban particulate matter samples
SETAC Europe 12th Annual Meeting (Abstract Book), year: 2002
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Chemické a biologické zbraně lákají jsou levné a dostupné
Hospodářské noviny(věda a technika), year: 2002, volume: 23.10.2002, edition: 1
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Chemické zbraně bývají vysoce účinné
Hospodářské noviny (Věda a technika), year: 2002, volume: 12.9.2002, edition: 1
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Chronic venous insufficiency - epidemiology
Bratislavske Lekarske listy, year: 2002, volume: 2002, edition: 103
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In vitro biotesty pro detekci negenotoxických procesů - studie efektů PAHs a hydroxyderivátů PCBs
Sborník pracovní konference - Ekotoxikologické Biotesty I, Seč u Chrudimi, 18-19/9/2002, year: 2002
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Inhibition of gap junctional intercellular communication and the activation of mitogen activated protein kinase by PCBs depends on substitution of chlorine ortho-position
Book of Abstracts - The 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs Emphasis on the latest advances and the perspective of Central and Eastern Europe. Brno, CR, 07-11/05/2002, year: 2002