Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2003
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Regionální chemoperfuze hrudníku kombinovaná se systémovou chemoterapií u pacientů s inoperabilním nemalobuněčným bronchogenním karcinomem - pilotní studie
Edukační sborník, year: 2003
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Results of treatment with gefitinib ("Iressa",ZD1839) in 45 patients with advanced non-small-cell lung cancer
Woorkbook of Iressa Clinical Experience Meeting, year: 2003
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Second-line treatment with gefitinib (Iressa, ZD 1839) in patient with advanced non-small-cell lung cancer.
Woorkbook of Iressa Clinical Experience Meeting, year: 2003
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Současná komplexní léčba nádorů hlavy a krku
Year: 2003, edition: Vyd. 1., number of pages: 67 s.
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Sources and forms of radiological and nuclear terrorism
2nd World Congress on Chemical, Biological and Radiological Terrorism CBMTS Industry III, Dubrovnik 2003, Abstracts of Papers, year: 2003
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Stockholm Convention (2001) on persistent organic pollutants and problems of its implementation in the Central-East European Region
Industrial Toxicology 03, year: 2003
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Sublethal effects of short chain chlorinated paraffins (SCCPs) identified with frog embryo assay FETAX. Persistent Toxic Substances Contamination of the European Region
RECETOX EU-Center of Excellence 1st Workshop, year: 2003
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The scientific community and chemical disarmament
INESAP Information Bulletin, year: 2003, volume: 22, edition: 1
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Toxicita chloračních činidel a jejich produktů ve vodním prostředí
11. konference s mezinárodní účastí Toxicita a biodegradabilita látek a odpadů významných ve vodním prostředí, Velké Karlovice, Soláň, 2003, Sborník referátů, year: 2003
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UNIDO/GEF Project on the implementation of the Stockholm Convention on persistent organic pollutants (POPs Convention) in the Central and Eastern European Countries
International Conference Persistent Toxic Substances Contamination of the European Region, Brno 2003, Book of abstracts., year: 2003