Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2004
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The Chemical Weapons Convention and the Role of Engineers and Scientists
Year: 2004, number of pages: 12 s.
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The impact of scientific and technological development on the Chemical Weapons Convention: Threats and benefits
FOGELBERG P. (Ed.): Changing Threats to Global Security: Peace or Turmoil, year: 2004, number of pages: 11 s.
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The Use of RP-HPLC for Separation of Polycyclic Aromatic Nitrogen Heterocycles
Abstracts-9th FECS Conference on Chemistry and the Environment, 2nd SFC meeting on Environmental Chemistry, year: 2004
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Toxicity increases in ice upon containing monochlorophenols upon photolysis: environmental consequences
Environmental Science & Technology, year: 2004, volume: 38, edition: 10
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Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells
Chemical Research in Toxicology, year: 2004, volume: 17, edition: -
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Transfekce dendritických buněk v nádorové imunoterapii.
Laboratorní hematologie, year: 2004
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Ultraterrorism and global agreements on combating international terrorism: Approach of European Union and of other regional and transnational political organisations
7. mezinárodní konference Krizové řízení 2004: Krizové řízení v nové Evropě, year: 2004
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Velké havárie a katastrofy I. Úvod nového seriálu
Rescue Report, year: 2004, volume: 7, edition: 4
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Velké havárie a katastrofy II. Utajené havárie jaderné výzbroje
Rescue Report, year: 2004, volume: 7, edition: 5
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Velké havárie a katastrofy III. Největší důlní katastrofa
Rescue Report, year: 2004, volume: 7, edition: 6