Project information
WNT-mediated signal relay in stem cells and oncogenesis - from basic biology to applications
(WntsApp)
- Project Identification
- 608180
- Project Period
- 8/2013 - 7/2017
- Investor / Pogramme / Project type
-
European Union
- 7th Specific RTD Programme
- People
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
-
University of Cambridge
Universität Würzburg
Universiteit Utrecht
Hebrew University of Jerusalem
University Medical Center Utrecht
- Responsible person Dr. Madelon Maurice
The ITN WntsApp is organized to achieve 3 key aims: (i) Provide a committed training programme for young researchers to bridge the gap between basic scientific knowledge and drug development, (ii) Centring research on a key cancer-signalling pathway, WNT signalling, to stimulate synergies and (iii) Strengthening the link between international partners and private enterprises to stimulate innovation and facilitate exploitation of results. We have recruited ten full partners from academia and industry from seven EU countries, providing a highly interactive research and training programme. Fellows get exposed to a wide range of activities in the private sector, including biotechnology and drug development, but also the publishing business. WntsApp fellows also profit from the activities of the SME PCDI, who are professionals in advising and supporting young graduates researchers.
The scientific focus will be on the WNT signalling pathway that mediates critical cell fate decisions and is strongly linked to cancer. The fellows will address the mechanisms that relay cellular WNT signals from the membrane to the cytosol and
nucleus, at the atomic, molecular and organismal level. The underlying molecular mechanisms provide attractive drug targets, particularly in regenerative medicine and cancer treatment. We will study and interfere with WNT signalling at various levels, focusing on conceptual advances regarding receptor specificity, allosteric effects, assembly and disassembly of complexes, WNT-regulated conformational changes, regulation of protein stability, role of molecular chaperones, proteinprotein
interactions, consequences for stem cell maintenance, mutation-induced tumourigenesis and the generation of high affinity agonists and antagonists that modulate receptor activity. The coherent class of students working on this
multidisciplinary theme will create synergisms, stimulate associated graduate schools and offer new opportunities for exploitation of results.
Publications
Total number of publications: 4
2022
-
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Frontiers in Cell and Developmental Biology, year: 2022, volume: 10, edition: February 2022, DOI
2019
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Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1
Nature Communications, year: 2019, volume: 10, edition: APR 18 2019, DOI
2018
-
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization
Journal of Biological Chemistry, year: 2018, volume: 293, edition: 48, DOI
2016
-
Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins
Proceedings of the National Academy of Sciences of the United States of America, year: 2016, volume: 113, edition: 33, DOI