Protein enginnering of mannosidase

Warning

This publication doesn't include Faculty of Sports Studies. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	DEMO Gabriel HORSKÁ Veronika FRIEDLOVA Barbora WEIGNEROVA Lenka WIMMEROVÁ Michaela
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	N-Acetyl-D-mannosamine (ManNAc) is often used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ManNAc is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. The main goal of this work is to produce N-acetyl-mannosaminidase via mutagenesis of mannosidase and to employ it in enzymatic synthesis of compounds containing ManNAc.
Related projects:	Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur