Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population

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Authors	HÉŽOVÁ Renata BIENERTOVÁ VAŠKŮ Julie ŠACHLOVÁ Milana BŘEZKOVÁ Veronika VAŠKŮ Anna SVOBODA Marek RADOVÁ Lenka KISS Igor VYZULA Rostislav SLABÝ Ondřej
Year of publication	2012
Type	Article in Periodical
Magazine / Source	European Journal of Medical Research
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://ww.eurjmedres.com/content/17/1/17
Doi	http://dx.doi.org/10.1186/2047-783X-17-17
Field	Oncology and hematology
Keywords	Colorectal cancer; GSTA1; GSTT1; GSTM1; GSTP1; Polymorphism
Description	Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione Stransferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics. In this study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.
Related projects:	CEITEC - Central European Institute of Technology