Význam mikroprostředí kostní dřeně v patogenezi mnohočetného myelomu

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Title in English	Implication of Bone Marrow Microenvironment in Pathogenesis of Multiple Myeloma
Authors	FIŠEROVÁ Barbora KUBICZKOVÁ Lenka ŠEVČÍKOVÁ Sabina HÁJEK Roman
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Klinická onkologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	Multiple myeloma; bone marrow microenvironment; pathogenesis; treatment
Attached files	Fiserova_et_al_KO.pdf
Description	Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.
Related projects:	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií Úloha mitotické disrupce v B lymfocytech u mnohočetného myelomu