Význam mikroprostředí kostní dřeně v patogenezi mnohočetného myelomu

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Title in English Implication of Bone Marrow Microenvironment in Pathogenesis of Multiple Myeloma
Authors

FIŠEROVÁ Barbora KUBICZKOVÁ Lenka ŠEVČÍKOVÁ Sabina HÁJEK Roman

Year of publication 2012
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Multiple myeloma; bone marrow microenvironment; pathogenesis; treatment
Attached files
Description Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.
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