BAFF Levels Are Elevated in Paediatric Patients With Acute Lymphoblastic Leukaemia Compared to Other B-Lineage Neoplasms

Warning

This publication doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	BIENERTOVÁ VAŠKŮ Julie BIENERT Petr KODYTKOVÁ Daniela ZLÁMAL Filip TOMANDL Josef TOMANDLOVÁ Marie VAŠKŮ Anna ŠTĚRBA Jaroslav
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Journal of Hematology
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.4021/jh104e
Field	Oncology and hematology
Keywords	B-cell activating factor; Acute lymphoblastic leukaemia; B-cell lymphoma; Paediatric
Attached files	JH_BAFF.pdf
Description	There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients (Bcp-ALL: 7764 plus-minus 6329 pg/ml, Bcell lymphoma: 2675 plus-minus 1544 pg/ml; P = 0.0268), the circulating levels of BAFF being substantially higher in B-ALL cases.