B-cell activating factor: variability of selected exonic regions and association with acute lymphoblastic leukemia in paediatric patients

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Authors

KALINA Dale Robert NORDHEIM Vegard Aas-Aune ŠPLÍCHAL Zbyněk BIENERTOVÁ VAŠKŮ Julie TOMANDL Josef JURAJDA Michal BIENERT Petr KŘENOVÁ Zdenka ŠTĚRBA Jaroslav VAŠKŮ Anna

Year of publication 2012
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Introduction: There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF, TNFSF13B) that enables the B cells to escape apoptosis. The aim of our study was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. Materials and methods: This cross-sectional study included the total of 18 children with B-lineage neoplasms whose serum levels of BAFF before the start of the treatment were examined using the ELISA-based methodology. Exons 1, 4 and 5 of BAFF gene were investigated using the direct sequencing in all patients. Results: We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients, the circulating levels of BAFF being substantially higher in B-ALL cases than in B-cell lymphoma cases. However, no genetic variability was observed in any of examined exonic regions of BAFF gene. Discussion: This is the first study to report elevated BAFF levels in acute lymphoblastic leukemia in children. Although highly limited in number of cases, our study provides a potential basis for further evaluation of BAFF as a diagnostic and/or prognostic marker in B-ALL.

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