Elevace plazmatických hladin BAFF (B-cell activating factor) u pediatrických pacientů s akutní lymfoblastickou leukémií oproti B-lymfomům

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Title in English	Elevation of B-cell activating factor (BAFF) levels in paediatric patients with acute lymphoblastic leukemia compared to other B-lineage malignancies
Authors	BIENERTOVÁ VAŠKŮ Julie KALINA Dale Robert NORDHEIM Vegard Aas-Aune ŠPLÍCHAL Zbyněk ZLÁMAL Filip TOMANDL Josef TOMANDLOVÁ Marie KODYTKOVÁ Daniela VAŠKŮ Anna ŠTĚRBA Jaroslav
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients, the circulating levels of BAFF being substantially higher in B-ALL cases.
Related projects:	Příspěvek chemických a biochemických metodik ke studiu molekulární podstaty vybraných patologických stavů a onemocnění