Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Ceska a Slovenska Neurologie a Neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.csnn.eu/en/czech-slovak-neurology-article/cognitive-effects-of-long-term-treatment-with-waking-hour-subcutaneous-apomorphine-infusions-in-patients-with-adv-35795?confirm_rules=1 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Affective; Apomorphine; Cognitive; Dementia; Parkinson's disease |
| Attached files | |
| Description | Aims: To determine whether long-term treatment with continuous subcutaneous apomorphine infusions (CSAI) is safe for patients with Parkinson's disease (PD) with a history of hallucinations and/or marked cognitive deficit. Methods: 12 PD patients (9 men, 3 women; age 71.8 +- 6 years) were given neuropsychological assessment prior to continuous administration of CSAI and fourteen months after it. Results: CSAI led to clinical improvement, at least minimal, in all subjects. However, the treatment led to statistically significant impairment in verbal fluency tasks, the Mattis dementia rating scale (MDRS) score and the attention and initiation subtests. No mood changes were detected. Conclusions: We observed significant impairment in "frontal-like" tasks after continuous treatment with CSAI in our PD patients with baseline cognitive impairment. Further longitudinal controlled studies are needed to assess the impact of both CSAI and PD progression. We suggest cautious selection of patients eligible for CSAI therapy with respect to their cognitive profiles and/or neuropsychiatric complications. |
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