Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia

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Authors

SOŠKA Vladimír DOBŠÁK Petr DUŠEK Ladislav SHIRAI Kohji JARKOVSKÝ Jiří NOVÁKOVÁ Marie BRHEL Petr ŠŤASTNÁ Jana FAJKUSOVÁ Lenka FREIBERGER Tomáš YAMBE Tomoyuki

Year of publication 2012
Type Article in Periodical
Magazine / Source JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords Atherosclerosis; Cardio-ankle vascular index; Familial hypercholesterolemia; Statins; Ezetimibe
Attached files
Description Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls. Methods: 82 FH subjects (27 males, 65 females), aged 53.7 +/- 13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9 +/- 14.9 years, were examined. CAVI was measured using the system VaSera (R) 1500. Results: CAVI in FH patients was significantly higher (8.0 +/- 1.4) than in healthy subjects (7.5 +/- 1.3) p=0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p=0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7). Conclusion: The study showed no significant difference in CAVI between heterozygous FH and healthy controls.
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