Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

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Authors	HÉŽOVÁ Renata KOVAŘÍKOVÁ Alena BIENERTOVÁ VAŠKŮ Julie ŠACHLOVÁ Milana RÉDOVÁ Martina VAŠKŮ Anna SVOBODA Marek RADOVÁ Lenka KISS Igor VYZULA Rostislav SLABÝ Ondřej
Year of publication	2012
Type	Article in Periodical
Magazine / Source	World Journal of Gastroenterology
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.wjgnet.com/1007-9327/full/v18/i22/2827.htm
Doi	http://dx.doi.org/10.3748/wjg.v18.i22.2827
Field	Oncology and hematology
Keywords	Association study; Colorectal cancer; MicroRNA; Single nucleotide polymorphism
Description	In order to investigate the effect of selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.The genotype and allele frequencies of SNPs were compared between the cases and the controls. Unfortunately, none of the performed analysis showed any statistically significant results. Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer.
Related projects:	CEITEC - Central European Institute of Technology