Studium vybraných transkribovaných ultrakonzervovaných regionů (T-UCR) u pacientů s kolorektálním karcinomem

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Title in English	Study of selected ultraconserved regions (T-UCR) in colorectal cancer patients.
Authors	ŠÁNA Jiří HANKEOVÁ Simona SVOBODA Marek NĚMEČEK Radim VYZULA Rostislav SLABÝ Ondřej
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequences longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.
Related projects:	CEITEC - Central European Institute of Technology