Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer

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Authors	ŠÁNA Jiří HANKEOVÁ Simona SVOBODA Marek KISS Igor VYZULA Rostislav SLABÝ Ondřej
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Oncology
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.karger.com/Article/Fulltext/336479
Doi	http://dx.doi.org/10.1159/000336479
Field	Oncology and hematology
Keywords	Colorectal cancer; Non-coding RNAs; Transcribed ultraconserved regions; uc.73; uc.388
Description	The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequenc es longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.
Related projects:	CEITEC - Central European Institute of Technology