Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer

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Authors

ŠÁNA Jiří HANKEOVÁ Simona SVOBODA Marek KISS Igor VYZULA Rostislav SLABÝ Ondřej

Year of publication 2012
Type Article in Periodical
Magazine / Source Oncology
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.karger.com/Article/Fulltext/336479
Doi http://dx.doi.org/10.1159/000336479
Field Oncology and hematology
Keywords Colorectal cancer; Non-coding RNAs; Transcribed ultraconserved regions; uc.73; uc.388
Description The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequenc es longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.
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