The role of c-Myb in control of migration, invasiveness and death of colon carcinoma cells

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Authors

PEKARČÍKOVÁ Lucie KNOPFOVÁ Lucia BURŠÍKOVÁ Jana POTĚŠIL David KONEČNÁ Hana ŠMARDA Jan

Year of publication 2012
Type Article in Proceedings
Conference The Student Scientific Conference on Biotechnology & Biomedicine
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords c-Myb; migration; invasivity; death; colon carcinoma cells
Description c-Myb is a transcription factor that is essential for hematopoiesis and plays important role in formation of colon epithelium. Overexpression of c-Myb has been associated with oncogenic activity and poor prognosis of colon carcinoma patients. Mechanism how c-myb controls the colon tumorigenesis remains unclear. Our results show that overexpressed c-Myb significantly potentiated migration and invasiveness of cells CT26. We analysed secretome of CT26MYBup and control cells by 2-DE followed by LC-MS/MS analysis of differential protein spots. We found protein MIF and galectin-1 as a proteins differentially secreted from CT26MYBup and control cells. c-Myb can regulate tumorigenicity of cells by enhancing of migration and invasive activity, by secretion of MIF and galectin-1 and by imposing resistance of cells to chemoterapeutics.
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