Identification and functional screening of microRNAs highly deregulated in colorectal cancer

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Authors

FALTEJSKOVÁ Petra SVOBODA Marek ŠRŮTOVÁ Klára MLČOCHOVÁ Jitka BEŠŠE Andrej NEKVINDOVÁ Jana RADOVÁ Lenka FABIAN Pavel SLABÁ Kateřina KISS Igor VYZULA Rostislav SLABÝ Ondřej

Year of publication 2012
Type Article in Periodical
Magazine / Source Journal of Cellular and Molecular Medicine
MU Faculty or unit

Central European Institute of Technology

Citation
Web
Doi http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x
Field Oncology and hematology
Keywords apoptosis; colorectal cancer; expression profilin; microRNA; migration
Description The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.
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