Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

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Authors	FALTEJSKOVÁ Petra BEŠŠE Andrej ŠEVČÍKOVÁ Sabina KUBICZKOVÁ Lenka SVOBODA Marek ŠMARDA Jan KISS Igor VYZULA Rostislav SLABÝ Ondřej
Year of publication	2012
Type	Article in Periodical
Magazine / Source	International Journal of Colorectal Disease
MU Faculty or unit	Central European Institute of Technology
Citation
web	http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
Doi	http://dx.doi.org/10.1007/s00384-012-1461-3
Field	Oncology and hematology
Keywords	miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration
Description	MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.
Related projects:	The role of c-Myb and Cox-2 proteins in colon carcinogenesis CEITEC - Central European Institute of Technology