Regulatory T Cells Predicts Progression in Previously Untreated Myeloma Patients and Treatment by Cyclophosphamide, Thalidomide Plus Dexamethasone Reduces Regulatory T Cells

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Authors	MUTHU RAJA Karthick Raja KOVÁŘOVÁ Lucie KAISAROVÁ P BARTOŇOVÁ Jana HÁJEK Roman
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Regulatory T (Treg) cells are one of the master regulators in maintaining tolerance and immune homeostasis. Several studies in hematological and non-hematological malignancies revealed that increased level of Treg cells significantly impede the anti-tumor responses. Moreover, in non-hematological malignancies Treg cells correlate inversely with patient's survival (Beyer et al, 2006, Blood). Here in this study we evaluated the prognostic significance of Treg cells in multiple myeloma (MM) patients and influence of chemotherapies on Treg cells.
Related projects:	University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies Vytvoření prognostického panelu u pacientů s monoklonální gamapatií nejasného významu s cílem zabránění transformace v maligní onemocnění Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií