Human nucleosomes: special role of CG dinucleotides and Alu-nucleosomes

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Authors

BETTECKEN Thomas FRENKEL Zakharia M. TRIFONOV Eduard

Year of publication 2011
Type Article in Periodical
Magazine / Source BMC Genomics
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.biomedcentral.com/1471-2164/12/273
Doi http://dx.doi.org/10.1186/1471-2164-12-273
Field Genetics and molecular biology
Keywords NUCLEOTIDE-SEQUENCE; DNA METHYLATION; CHROMATIN DNA; PATTERN; ELEGANS; CORE; RESOLUTION; POSITION; ELEMENTS; GENOME
Description The periodical occurrence of dinucleotides with a period of 10.4 bases now is undeniably a hallmark of nucleosome positioning. Considering the exceptional role CG dinucleotides play in the nucleosome positioning, we hypothesize that Alu-nucleosomes, especially, those that form tightly positioned runs, could serve as "anchors" in organizing the chromatin in human cells.
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