Endomyokardiální biopsie u recentní dilatační kardiomyopatie – zhodnocení vstupních charakteristik prvních padesáti nemocných
| Title in English | Endomyocardial biopsy in recent dilated cardiomyopathy – evaluation of baseline characteristics of the first 50 patients |
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| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Cor et Vasa |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Dilated cardiomyopathy; Inflammatory cardiomyopathy; Endomyocardial biopsy; Echocardiography; Right-heart catheterization |
| Description | The aim was to evaluate bioptic findings in patients with recent non-ischemic heart failure and to compare the baseline clinical, echocardiographic, hemodynamic and some laboratory parameters in the groups with and without confirmed myocarditis. The study population comprised 50 patients with recent DCMP who underwent – besides standard investigations – a detailed echocardiographic evaluation using pulse wave tissue Doppler imaging (TDI), right-heart catheterization and right ventricular EMB. Bioptic specimens were examined histologically, immunohistochemically and using molecular genetic evaluation by polymerase chain reaction (PCR). The patients were divided into two groups according to the EMB findings – inflammatory cardiomyopathy (ICM) group and non-inflammatory dilated cardiomyopathy (DCM) group – and these two groups were then compared. In our population, recent DCM had inflammatory origin in 56% cases. Viral genome was found in the myocardium of 58% patients. Compared with ICM patients, non-inflammatory DCM patients had larger left ventricular systolic and diastolic diameter, larger left ventricular EDV and ESV and also larger right ventricular dimension. ICM patients had shorter symptom duration and their MPA and PCW pressures were lower. No significant differences between the groups were detected concerning other clinical, laboratory and echocardiographic parameters including TDI characteristics. |
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