A new approach how to define coefficient of electroactivity of adenine and its twelve derivatives using flow injection analysis with amperometric detection.

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Authors

ZÍTKA Ondřej SKUTKOVA Helena ADAM Vojtěch TRNKOVÁ Libuše BABULA Petr HUBÁLEK Jaromír PROVAZNÍK Ivo KIZEK René

Year of publication 2011
Type Article in Periodical
Magazine / Source Electroanalysis
MU Faculty or unit

Faculty of Science

Citation
Web http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=17&SID=V254NakJe2LpBEPl4g1&page=1&doc=1
Doi http://dx.doi.org/10.1002/elan.201100064
Field Physical chemistry and theoretical chemistry
Keywords Adenine derivatives; Flow injection analysis; Amperometric detection; Glassy carbon electrode; Electroactivity
Description We studied the electrochemical behaviour of adenine derivates (adenosine, 2-aminopurine, 2,6-diaminopurine, 6-benzyl-aminopurine, adenosine monophosphate, cyclic adenosine monophosphate, nicotinamide adenine dinucleotide, adenosine triphosphate, S-adenosyl-L-methionine, and synthetic derivatives AD-3, AD-6 and AD-9) using flow injection analysis with electrochemical detection using a glassy carbon electrode. The influences of pH, flow rate and potential on the signal height of the studied derivates were tested. The optimal pH was 3, the flow rate of the mobile phase 0.75 mLmin(-1) and the potential 1100 mV. Further, we attempted to characterize each of the studied derivatives by mathematical equations and classic analytical parameters. The lowest detection limit was estimated for adenine as 0.9 nM and 2-aminopurine as 0.5 nM.
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