The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.

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Authors

BENÍŠEK Martin KUBINCOVÁ Petra BLÁHA Luděk HILSCHEROVÁ Klára

Year of publication 2011
Type Article in Periodical
Magazine / Source Toxicology Letters
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1016/j.toxlet.2010.11.011
Field Environment influence on health
Keywords retinoids; differentiation; Oct-4; PAHs; N-PAHs
Description This study investigated PAHs and N-PAHs interference with retinoid signaling in vitro by modulating all-trans retinoic acid (ATRA) mediated response in a reporter gene assay using P19/A15 cell line. Further, effects on pluripotency and differentiation processes were evaluated by measuring octamer-4 (Oct-4), an important pluripotency marker and master differentiation factor. Our results further extend the knowledge of PAH and N-PAH in vitro effects and indicate that these environmental toxicants may have influence on differentiation process and embryonic development by interfering with ATRA signaling and by modulating levels of Oct-4.
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