Bilateral elevation of TNFa and IL-6 mRNAs in dorsal root ganglia alongside neuroaxis following unilateral nerve injury

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Authors

BRÁZDA Václav KLUSÁKOVÁ Ilona HRADILOVÁ SVÍŽENSKÁ Ivana DUBOVÝ Petr

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Cytokines are injury-induced inflammatory mediators that contribute to both induction and maintenance of neuropathic pain. We used in situ hybridization and quanitative RT-PCR to provide evidence that unilateral chronic constriction injury (CCI) of the sciatic nerve induces synthesis of TNFa and IL-6 in DRG of different spinal cord segments alongside neuroaxis.
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