Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | BMC Neuroscience |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.biomedcentral.com/1471-2202/12/58 |
| Doi | http://dx.doi.org/10.1186/1471-2202-12-58 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | NEURON REGENERATION ACCURACY; PERIPHERAL-NERVE; BRACHIAL-PLEXUS; SCHWANN-CELLS; ULNAR NERVE; SKELETAL-MUSCLE; SCIATIC-NERVE; FACTOR CNTF; ADULT-RAT; IGF-I |
| Attached files | |
| Description | Repair nerve if proximal stump is unavailable and autogenous nerve grafts are insufficient for reconstructing extensive nerve damage is difficult. Alternative methods have been developed, including lateral anastomosis based on axons’ ability to send out collateral sprouts into denervated nerve. The aim of this study was to quantitatively assess collateral sprouts sent out by intact motor and sensory axons in the end-to-side neurorrhaphy model following intrathecal administration of CNTF in comparison with phosphate buffered saline and Cerebrolysin. The distal stump of rat transected musculocutaneous nerve was attached in an end-to-side fashion with ulnar nerve. Animals were allowed to survive for 2 months. The present experimental study confirms end-to-side neurorrhaphy as an alternative method for reconstructing severed peripheral nerves. CNTF promotes motor reinnervation of the MCN stump after its end-toside neurorrhaphy with ulnar nerve and improves functional recovery of the biceps brachii muscle. |
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