Nový lektin ze světélkující bakterie Photorhabdus luminescens

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Title in English	New lectin from bioluminescent bacterium Photorhabdus luminescens
Authors	ROZUMOVÁ Petra WIMMEROVÁ Michaela
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	The protein PLU from P. luminescens has a strong sequence homology with characterized lectin BC2L-C-nt from the human opportunistic pathogen Burkholderia cenocepacia. So far, PLU is the only one supposed homologous of BC2L-C-nt lectin. Function studies were performed using surface plasmon resonance and isothermal titration calorimetry, which allowed identifying binding properties and thermodynamic parameters of interaction with saccharides. Preliminary information about a quaternary structure of the protein was obtained using dynamic light scattering, crosslinking with bifunctional reagents and analytical ultracentrifugation.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Lectins from human pathogens - structure, function, engineering Molekulární a strukturní biologie vybraných cytostatik. Od mechanických studií k chemoterapii rakoviny