Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2005
Type	Appeared in Conference without Proceedings
MU Faculty or unit	Faculty of Medicine
Citation
Description	We conclude that ajmaline is a potent blocker of IK(ATP), INa and Ito. In rat ventricular myocytes, block of INa is responsible for the decrease in upstroke velocity and the decline in AP amplitude. The main determinant of AP prolongation is block of Ito. Ajmaline is an open state blocker of Ito with fast recovery kinetics manifested in frequency independence of block.
Related projects:	Early diagnostics and treatment of cardiovascular diseases