Mutagenesis of Lectin PA-IIL from Pseudomonas aeruginosa as a Tool for Preparation of Lectins with Tune Specificity and Affinity

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Authors	POKORNÁ Martina ADAM Jan MRÁZKOVÁ Jana IMBERTY Anne KOČA Jaroslav WIMMEROVÁ Michaela
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Carbohydrate-mediated recognition plays an important role in the ability of pathogenic bacteria to adhere to the surface of the host cell in the first step of their invasion and infectivity. A saturated mutagenesis of the specificity binding loop of PA-IIL lectin in silico was performed and selected mutants have been studied in vitro.
Related projects:	Lectins from human pathogens - structure, function, engineering