Mutagenesis of Lectin PA-IIL from Pseudomonas aeruginosa as a Tool for Preparation of Lectins with Tune Specificity and Affinity

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Authors

POKORNÁ Martina ADAM Jan MRÁZKOVÁ Jana IMBERTY Anne KOČA Jaroslav WIMMEROVÁ Michaela

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Carbohydrate-mediated recognition plays an important role in the ability of pathogenic bacteria to adhere to the surface of the host cell in the first step of their invasion and infectivity. A saturated mutagenesis of the specificity binding loop of PA-IIL lectin in silico was performed and selected mutants have been studied in vitro.
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