Vztah progrese diabetické nefropatie a mortality k funkčnímu deficitu pentózového jako důsledku abnormálního metabolizmu thiaminu u DM

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Title in English Relation between progression of diabetic nephropathy and mortality and.the functional deficiency of pentose phosphate cycle enzymes as a result of abnormality in thiamine status in diabetic patients
Authors

KRUSOVÁ Darja PÁCAL Lukáš KAŇKOVÁ Kateřina SVOJANOVSKÝ Jan TOMANDL Josef OLŠOVSKÝ Jindřich

Year of publication 2010
Type Article in Periodical
Magazine / Source Aktuality v nefrologii
MU Faculty or unit

Faculty of Medicine

Citation
Field Other medical specializations
Keywords diabetic nephropathy; pentose phosphate cycle; thiamin
Description The results support the role of functional thiamine deficiency in the development of hyperglycaemia- related pathology. Limited intracellular availability of active TKT co-factor seems to be a dominant abnormality.
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