Electrophysiological Effects of Voltage Sensitive Dye di-4-ANNEPS in Rabbit and Guinea Pig Isolated Heart.

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Authors	FIALOVÁ Kateřina KOLÁŘOVÁ Jana SEKORA Jiří TANNENBERG Milan NOVÁKOVÁ Marie PROVAZNÍK Ivo
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Mapping of cardiac electrical activity using voltage-sensitive dyes (VSDs) is considered to be a valuable method for electrophysiological studies. VSDs undergo changes in their electronic structure, and consequently their fluorescence spectra, in response to changes in the surrounding electric field and therefore may be used for recording of monophasic action potentials (MAPs). Staining of the heart tissue with the dye should not result in pharmacological or toxic effects. VSD di-4-ANEPPS is currently used in our laboratory for recording of MAPs in isolated hearts. This paper presents continuation of our previous study focused on examination of electrophysiological effects of this dye on rabbit and guinea pig isolated hearts. Electrograms, recorded during staining with the dye and washout from it, were compared and the types and frequency of dysrhythmias evaluated.
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