Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents

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Authors

LUBAL Přemysl VANĚK Jakub ŠEVČÍKOVÁ Romana POLÁŠEK Miloslav HERMANN Petr LUKEŠ Ivan

Year of publication 2010
Type Article in Proceedings
Conference Abstract book of XIV. Symposium on Luminescence Spectrometry
MU Faculty or unit

Faculty of Science

Citation
Field Analytic chemistry
Keywords Macrocyclic ligand; Ln(III) ions; thermodynamics; kinetics; photophysics; analytical determination
Description Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine. The molecular spectroscopy in UV/VIS region was employed to investigate chemical features of Eu(III)/Gd(III)/Tb(III) complexes of the title ligand in order to investigate their possible applications as bimodal agents. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. In the study of formation (pH = 5.0-6.0, t = 25 C, I = 0.1 M KCl) was found that the reactive species is HL 2- and the rate increases with decreasing ionic radius of the metal ions and it follows a trend along the Ln(III) series. The ligand capable of complex formation due show interesting photophysical properties to presence of chromophor/fluorophor group and it enables to determine the low concentration of Eu(III)/Tb(III) ions.
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