Flow Cytometric Phenotyping and Analysis of CD8 Regulatory and Suppressor Cells In Multiple Myeloma

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Authors

MUTHU RAJA Karthick Raja KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana HÁJEK Roman MICHÁLEK Jaroslav

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description In solid tumors and hematological malignancies, elevated proportions of CD4 regulatory (CD4 Tregs) cells were reported and the function was also documented well. In the context of CD8 regulatory cells (CD8 Tregs) existence has been revealed in various solid tumors including colorectal, prostate and ovarian cancers. In hematological malignancies or multiple myeloma (MM) the presence of CD8 Tregs are yet to be revealed. To unveil and understand the existence of CD8 Tregs, we characterized and quantified CD8 Tregs along with CD8 suppressor cells in MM.
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