Nové možnosti v laboratorní diagnostice nádoru prostaty

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Title in English New possibilities in laboratory diagnosis of prostate cancer
Authors

GUMULEC Jaromír MASAŘÍK Michal KŘÍŽKOVÁ Soňa BABULA Petr HRABEC Roman ROVNÝ Arne CERNEI Natalia Vladimirovna MASAŘÍKOVÁ Monika KIZEK René

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Malignant transformation of prostate cancer is associated with metabolic dysregulation of heavy metals. There is so - yet unknown mechanism - to raise serum levels of metallothionein (MT), low molecular weight cysteine-rich protein with antioxidant potential, compassionately detoxification of heavy metals. MT levels are significantly increased (p <0.01) in serum of patients with biopsy-proven acinar adenocarcinoma (the most common form of prostate Ca) on the staging of the T 1c-4, compared with the control group levels are increased more than threefold. Sensitivity increase is 100% of patients. MT levels are not dependent (correlation coefficient r <0.2 or higher and statistically insignificant) in the PSA for staging the disease and the presence of comorbidities hypertension, hyperlipoproteinemia and ischemic heart disease. MT levels decreased with increasing tumor grade (r = -0.3 at p <0.05).
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