Vliv zinku na nádorové buněčné linie odvozené od karcinomu prostaty

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Title in English	Zinc influence on cell lines derived from prostate cancer
Authors	SZTALMACHOVÁ Markéta GUMULEC Jaromír HLAVNA Marián BABULA Petr KŘÍŽKOVÁ Soňa ADAM Vojtěch ECKSCHLAGER Tomáš MASAŘÍK Michal KIZEK René
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	In our work we have focused on the analysis of tumor cell lines derived from prostate cancer and their influences various concentrations of zinc ions. We worked with three tumor lines (PC-3, LNCaP, 22Rv1) and one nonmalignant prostate cell lines (PNT1A). We performed first measurements using the classical MTT cytotoxicity test, and then also by real-time monitoring of cells using the apparatus XCELLigence. The results show that cell lines derived from normal prostate epithelium has a greater ability to accumulate zinc ions compared to tumor lines. Using your XCELLigence we obtained unique results that could contribute to clarify the metabolism of zinc in cancerous prostate tissue.
Related projects:	Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu