Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity

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Authors	JÍRA Miroslav ZÁVODNÁ Eva HONZÍKOVÁ Nataša NOVÁKOVÁ Zuzana VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie FIŠER Bohumil
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Physiological Research
MU Faculty or unit	Faculty of Medicine
Citation
Web	http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=X1EL3PjGbGJMeHdJIdi&page=1&doc=2
Field	Physiology
Keywords	baroreflex sensitivity; angiotensin II type 1 receptor; polymorphism; spectral analysis
Description	Diminished baroreflex sensitivity is connected with hypertension, cardiac failure and presents a risk factor for sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity in man. We found a significant association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity.
Related projects:	Early diagnostics and treatment of cardiovascular diseases